Espin dating site
CO;2-I" target="_blank" onclick="ga('send', 'event', ' Outbound', ' Publisher')"Zheng et al.(2000) determined that espins are present in hair cell stereocilia and uncovered a connection between the espin gene and jerker mouse, a recessive mutation that causes hair cell degeneration, deafness, and vestibular dysfunction.Indeed, mutations in one of the most prevalent deafness alleles in the CX26 gene can be inherited in either a dominant or recessive mode (Rabionet et al., 2000). (2000) determined that espins are present in hair cell stereocilia and uncovered a connection between the espin gene and jerker mouse, a recessive mutation that causes hair cell degeneration, deafness, and vestibular dysfunction.
ESPN expression constructs lacking either one or both of the actin-binding sites were unable to crosslink actin filaments when transfected into BHK fibroblasts. (1999) confirmed that mouse espin and small espin are splice variants of a single gene.9763424, images] [Full Text]" pmid="9763424"Naz et al. The deduced 854-amino acid protein has 8 ankyrin-like repeats at the N terminus, 2 proline-rich regions, a consensus site for ATP or GTP binding (P loop), which is contained within an actin-binding WH2 motif, and a coiled coil domain.The human protein shares 83% and 86% sequence identity with the mouse and rat homologs, respectively.The tissues of jerker mice did not accumulate espin proteins but contained normal levels of espin m RNAs.The authors identified a frameshift mutation in the espin gene of jerker mice that affected the espin C-terminal actin-bundling module.